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1.
Clinics in Orthopedic Surgery ; : 300-307, 2023.
Article in English | WPRIM | ID: wpr-966710

ABSTRACT

Background@#This study aimed to investigate the changes in the incidence of shoulder trauma and surgery 1 year after the outbreak of coronavirus disease 2019 (COVID-19) with social restriction compared with 1 year before the pandemic. @*Methods@#Patients managed in our orthopedic trauma center between February 18, 2020, and February 17, 2021 (COVID-19 period) for shoulder trauma were compared with patients managed for the same duration a year ago (non–COVID-19 period; February 18, 2019, to February 17, 2020). The incidence of shoulder trauma, surgery, and mechanism of injury were compared between these periods. @*Results@#The total number of shoulder trauma cases was lower in the COVID-19 period than in the non–COVID-19 period, although the difference was not significant (160 vs. 180 cases, p = 0.278). In addition, traumatic shoulder surgeries decreased during the COVID-19 period (57 vs. 69 cases, p = 0.285). The incidence of shoulder trauma according to four diagnostic classifications (contusion, sprain/subluxation, fracture, and dislocation) and fracture/dislocation types did not differ between the periods. During the COVID-19 period, accidental falls outdoors (45 vs. 67, p = 0.038) and sports-related injuries (15 vs. 29, p = 0.035) significantly decreased, but accidental falls at home (52 vs. 37, p = 0.112) increased compared with those during the non–COVID-19 period, although the difference was not significant. The monthly incidence of shoulder trauma decreased 2 months after the first outbreak (significant in March, p = 0.019), then steadily increased and significantly decreased during the second outbreak (August, p = 0.012).However, the third outbreak (December, p = 0.077) had little effect on the incidence of shoulder trauma. The number of monthly traumatic shoulder surgeries showed a similar pattern to the monthly incidence of shoulder trauma. @*Conclusions@#During the COVID-19 pandemic, annual shoulder trauma cases and surgeries decreased compared to those in the non–COVID-19 period, even though the difference was insignificant. The incidence of shoulder trauma and surgery was significantly reduced in the early COVID-19 period; however, the effect of the pandemic on orthopedic trauma practice was minimal after approximately half a year. Decreases in falls outdoors and sports-related injuries, but an increase in falls at home, were observed during the COVID-19 pandemic.

2.
The Journal of the Korean Society for Transplantation ; : 10-14, 2012.
Article in Korean | WPRIM | ID: wpr-209738

ABSTRACT

BACKGROUND: Kidney donation is a relatively safe procedure with minimal adverse effects. But some reports have described the development of proteinuria and hypertension in donors after nephrectomy. There have been a number of non-Korean studies which conclude that the procedure is relatively safe and a good quality of life is expected for living donors after kidney transplantation, but not enough of these studies have been published in Korea. We evaluated the physiologic and psychosocial impacts after kidney donation in this study. METHODS: Between April 1988 and April 2010, we performed 201 living donor nephrectomies and obtained information for 88 (43.7%) of the donors. We measured their estimated glomerular filtration rate (GFR), blood pressure, body mass index, hemoglobin and cholesterol level, and assessed the prevalence of hypertension and proteinuria in this group. These donors completed a questionnaire regarding their health status and psychosocial outcomes after donation. RESULTS: The average time of the donor assessment after nephrectomy was 95.05+/-85.45 months (range, 6~261). The left kidney was used in 76 patients (86%). There was a total complication rate of 8%, but no serious complications were observed. Proteinuria was found in 9 patients (10%) and hypertension in 11 patients (11%). GFR decreased from 103.65+/-25.02 mL/min to 76.12+/-19.90 mL/min (P<0.001) and hemoglobin decreased from 13.91+/-1.62 g/dL to 13.01+/-1.72 g/dL (P<0.001). Five patients (6%) developed a post-donation GFR between 40 and 60 mL/min, with 2 patients being observed to have a post-donation GFR below 20 mL/min. In the questionnaire responses, most donors did not report problems affecting routine life or any economic impact. Their donation satisfaction results were very high (92%). CONCLUSIONS: Living kidney donors were observed to result in reduced GFR after nephrectomy. Follow-up visits with living kidney donors is essential in order to monitor risk factors related to the deterioration of their residual kidney function.


Subject(s)
Humans , Blood Pressure , Body Mass Index , Cholesterol , Follow-Up Studies , Glomerular Filtration Rate , Hemoglobins , Hypertension , Kidney , Kidney Transplantation , Korea , Living Donors , Nephrectomy , Organothiophosphorus Compounds , Prevalence , Proteinuria , Quality of Life , Surveys and Questionnaires , Risk Factors , Tissue Donors
3.
Korean Journal of Gastrointestinal Endoscopy ; : 428-432, 2011.
Article in Korean | WPRIM | ID: wpr-150380

ABSTRACT

Hemobilia is a rare upper gastrointestinal (GI) bleeding phenomenon usually caused by trauma but may occur due to various liver and pancreatobiliary diseases. Causes related to gallbladder disease include vascular disorders, malignancy, polyps, heterotopic GI mucosa, acalculous inflammation, and most commonly gallstones. Most cases are treated with a cholecystectomy. If hemobilia is detected, efforts must be made to exclude malignancy because hemobilia develops from both benign and malignant disease. Particularly in gallbladder disease with hemobilia, the possibility of gallbladder carcinoma should be considered. We report two cases of hemoblia by endoscopic retrograde cholangiopancreatography and duodenoscopy, with a review of the literature. The first case was xanthoglanulomatous cholesystitis and the second case was gallbladder cancer disclosed by cholecystectomy.


Subject(s)
Cholangiopancreatography, Endoscopic Retrograde , Cholecystectomy , Cholecystitis , Duodenoscopy , Gallbladder , Gallbladder Diseases , Gallbladder Neoplasms , Gallstones , Granuloma , Hemobilia , Hemorrhage , Inflammation , Liver , Mucous Membrane , Polyps , Xanthomatosis
4.
Korean Journal of Physical Anthropology ; : 141-154, 2011.
Article in Korean | WPRIM | ID: wpr-28209

ABSTRACT

IL-17A is a pro-inflammatroy cytokine secreted by activated T cells. The IL-17 family consist of IL-17A, IL-17B, IL-17C, IL-17D, IL-17E and IL-17F. IL-17A and IL-17F are produced primarily in activated T cells. In contrast, IL-17B, IL-17C, IL-17D and IL-17E are expressed in a wide assortment of tissues. Their functions partially overlap those of IL-17A, although they have not been as thoroughly investigated. The receptor for IL-17A (IL-17R) is widely expressed in a variety of tissues. IL-17A and IL-17E mRNAs were expressed in only EL4 cells. IL-17C mRNA expression was observed in the thymic subcapsular/cortex epithelial cells (SNEC), cortex or cortical reticular cells (CREC), medullary epithelial cells (MEC), medullary interdigitating-like cells (MDC), thymocytes and EL4 cells. However, IL-17C mRNA was not expressed in RAW 264.7 cells. Immunohistochemical study also demonstrated not only the presence of IL-17A mainly in the thymic epithelial cells, but also the upregulated expression of IL-17A in the thymic epithelial cells of the regenerating thymus. Thus, the results of the present study suggest that IL-17A expressed in the thymocytes and thymic epithelial cells could play an important role in the development of new T cells to replace T cells damaged by cyclophosphamide treatment during thymus regeneration.


Subject(s)
Animals , Humans , Rats , Cyclophosphamide , Epithelial Cells , Interleukin-17 , Regeneration , RNA, Messenger , T-Lymphocytes , Thymocytes , Thymus Gland
5.
Journal of the Korean Child Neurology Society ; : 200-208, 2009.
Article in Korean | WPRIM | ID: wpr-121626

ABSTRACT

PURPOSE: Sleep disorder is common in childhood and adolescence with prevalence of 27-62%, and the patients could have trouble with their daily life due to fatigue and headache; and it can also cause developmental disability, learning disorder, anxiety disorder, and depressive disorder. We studied the prevalence of anxiety and depressive disorder in childhood and adolescence with sleep disorder. METHODS: We studied 34 cases of patients under twenty-year-old who took a sleep polysomnography test at Sleep Center of Keimyung University Dongsan Medical Center and who could answer sleep survey questionnaires; and we used testing methods of Questionnaire for insomnia, Epworth sleepness scale, Hospital Anxiety Depression Scale, and Back Depression Inventory. We studied sleep disorder as two categories of sleep apnea and other sleep disorders and also the relationships of sleep and anxiety and depressive disorder with chi-square test. RESULTS: 29.4% of sleep disorder patients had anxiety disorder, and 47.1% depressive disorder. Considering the two categories of sleep disorder, anxiety disorder was significantly higher(P<0.005) in sleep apnea group with 43.5% than in other sleep disorder group with 9.1%. Depressive disorder was also significantly higher(P<0.05) in sleep apnea group with 65.6% than in other sleep disorder group with 36.4%. CONCLUSION: The patients with sleep disorder also had a tendency of having mood disorder, with prevalence of 29.4% of anxiety disorder and 47.1% of depressive disorder; especially in the group of sleep apnea, mood disorders was significantly higher than other sleep disorder group, which means more aggressive diagnosis and treatment are needed for the combined condition of sleep and mood disorder.


Subject(s)
Adolescent , Humans , Anxiety , Anxiety Disorders , Depression , Depressive Disorder , Developmental Disabilities , Fatigue , Learning Disabilities , Mood Disorders , Polysomnography , Prevalence , Surveys and Questionnaires , Sleep Apnea Syndromes , Sleep Wake Disorders , Sleep Initiation and Maintenance Disorders
6.
Korean Circulation Journal ; : 352-358, 2009.
Article in English | WPRIM | ID: wpr-151437

ABSTRACT

BACKGROUND AND OBJECTIVES: Anthracyclines are effective drugs that are widely used in pediatric cancer treatment. Previous studies have demonstrated that exposure to low-dose anthracyclines (<300 mg/m2) induces a progressive decrease in cardiac function during long-term follow-up. The goal of this study was to assess left ventricular function using vector velocity imaging (VVI) in children undergoing low-dose anthracycline therapy. SUBJECTS AND METHODS: We examined 14 asymptomatic patients who had been treated with anthracyclines and had normal fractional shortening (FS) and ejection fraction (EF). In all of the patients, standard two-dimensional (2D) pulsed and tissue Doppler echocardiographic measurements were taken from an apical 4-chamber view. The peak myocardial velocity, peak strain rate (SR), peak strain, and displacement were obtained from VVI. Data were compared with 14 age-matched healthy controls. RESULTS: From the regional wall motion analysis using VVI in the left ventricle, the peak myocardial velocity and displacement of the lateral wall were increased significantly more than the septum, and there were no significant differences between the patients and the controls. Although systolic strain, and the systolic and diastolic SRs showed no significant differences between the septum and lateral wall in the controls, those of septum, in the patients, were decreased significantly more than those of lateral wall (p<0.05). In comparison with the controls, these changes in septal strain and SRs of patients were significant (p<0.05). CONCLUSION: Anthracycline therapy, even low-dose, can induce changes in regional wall function before global dysfunction. Also, the strain and SR obtained from VVI may be useful for early detection of these changes.


Subject(s)
Child , Humans , Anthracyclines , Displacement, Psychological , Follow-Up Studies , Heart Ventricles , Sprains and Strains , Ventricular Function, Left
7.
Korean Journal of Perinatology ; : 74-77, 2009.
Article in Korean | WPRIM | ID: wpr-92701

ABSTRACT

Blood was known as a potent inhibitor of pulmonary surfactant, and maternal blood aspiration is a rare cause of respiratory distress syndrome in neonates. We experienced a neonate with a history of maternal antepartum hemorrhage who developed respiratory distress after birth and blood was aspirated from tracheal suction. He received artificial ventilation and subsequent improvement of chest x-ray and oxygenation index was noted after artificial surfactant replacement therapy. The aspirated blood was of maternal origin.


Subject(s)
Humans , Infant, Newborn , Hemorrhage , Mothers , Oxygen , Parturition , Pulmonary Surfactants , Respiratory Distress Syndrome , Suction , Thorax , Ventilation
8.
The Korean Journal of Gastroenterology ; : 399-403, 2009.
Article in Korean | WPRIM | ID: wpr-60796

ABSTRACT

Hemangioma is one of the most frequently encountered benign hepatic neoplasm which can develop secondary degeneration. Sclerosed hemangioma is a rare disease histologically characterized by large amount of collagen and elastic fibril between sclerosed small vessels. Its differential diagnosis is very difficult. It should be included in the differential diagnosis of other hepatic lesions such as hepatocellular carcinoma, intrahepatic cholangiocarcinoma, and metastatic hepatic tumor. A 77-year old male was admitted with upper abdominal discomfort. Abdominal ultrasonography revealed GB stone, dilated common bile duct with bile duct stone, and a 4.6 cm sized hyperechoic mass at segment 5 and 6 of the liver. Abdominal dynamic computed tomography demonstrated dilated intrahepatic bile ducts and a 5x5 cm sized mass which showed minimally delayed enhancement. Abdominal magnetic resonance imaging revealed the mass with low signal intensity in T1 weighted image, high signal intensity and focal low signal in T2 weighted image which showed minimal enhancement. We removed common bile duct stone with endoscopic retrograde cholangiopancreatography then decided to undergo right lower segmentectomy of liver due to possibility of cholangiocarcinoma. Histopathological examination of hepatic mass showed large amount of fibrous tissue with occasional residual vascular channels. We describe one case of sclerosed hemangioma mimicking cholangiocarcinoma.


Subject(s)
Aged , Humans , Male , Bile Duct Neoplasms/diagnosis , Bile Ducts, Intrahepatic , Cholangiocarcinoma/diagnosis , Diagnosis, Differential , Hemangioma/diagnosis , Liver Neoplasms/diagnosis , Magnetic Resonance Imaging , Tomography, X-Ray Computed
9.
Journal of the Korean Knee Society ; : 244-247, 2007.
Article in Korean | WPRIM | ID: wpr-730976

ABSTRACT

Posterior instability after mobile bearing total knee replacement may be caused by gap imbalance, component malpo- sition, and delayed rupture of posterior cruciate ligament, but could not be easily considered other cause except component breakage in fixed bearing posterior cruciate substituted total knee replacement. The dislocation of tibial polyethylene insert was reported after mobile bearing total knee replacement but rare after fixed bearing total knee replacement. We report a case of dislocation of tibial polyethylene insert that have been found at a patient who had continuing posterior instability after fixed bearing posterior cruciate ligament substituted total knee replacement with a review of article.


Subject(s)
Humans , Arthroplasty, Replacement, Knee , Joint Dislocations , Polyethylene , Posterior Cruciate Ligament , Rupture
10.
Korean Journal of Hepato-Biliary-Pancreatic Surgery ; : 1-11, 2003.
Article in Korean | WPRIM | ID: wpr-113805

ABSTRACT

BACKGROUND/AIMS: Despite of increasing numbers of reports on intraductal papillary mucinous tumor (IPMT), there is still difficulty in its' diagnosis, treatment and prediction of prognosis. The purpose of this multicenter study was to evaluate the clinico-pathological features of IPMT in Korea and suggest the prediction criteria of malignancy in IPMT. METHODS: We retrospectively reviewed the clinico-pathological data of 208 patients who underwent operations with IPMT between 1993 and 2002 at 28 institutes in Korea. RESULTS: Of the 208 patients with a mean age of 60.5+/-9.7 years, 147 were men and 61 were women. 124 patients underwent pancreatoduodenectomy, 42 distal pancreatectomy, 17 total pancreatectomy, 25 limited pancreas resection. Benign cases were 128 (adenoma (n=62), borderline (n=66)) and malignant cases were 80 (non-invasive (n=29), invasive (n=51)). A significant difference in 5-year survival was observed between benign and malignant group (92.6% vs. 65.3%; p=0.006). Of the 6 factors (age, location, duct dilatation, tumor appearance, main duct type, and tumor size) that showed the statistical difference in univariate analysis between benign and malignant group, we found three significant factors (tumor appearance (p=0.009), tumor size (p=0.023), and dilated duct size (p=0.010)) by multivariate analysis. CONCLUSION: Although overall prognosis of IPMT is superior to ordinary pancreatic cancer, more curative surgery is recommended in malignant IPMT. Tumor appearance (papillary), tumor size (> or =30 mm) and dilated duct size (> or = 12 mm) can be used as preoperative indicators of malig-nancy in IPMT.


Subject(s)
Female , Humans , Male , Academies and Institutes , Diagnosis , Dilatation , Korea , Mucins , Multivariate Analysis , Pancreas , Pancreatectomy , Pancreatic Neoplasms , Pancreaticoduodenectomy , Prognosis , Retrospective Studies
11.
Korean Circulation Journal ; : 147-152, 2000.
Article in Korean | WPRIM | ID: wpr-222707

ABSTRACT

BACKGROUND AND OBJECTIVES: Although a prominent large V wave in left atrial pressure tracing (PVLAP) has been reported to be associated with significant mitral regurgitation (MR) or decreased left atrial compliance (LAC), it is sometimes observed in patients with tight mitral stenosis (MS). The purpose of this study was to determine the prevalence and the hemodynamic significance of PVLAP in tight MS. MATERIALS AND METHODS: Catheterization data before percutaneous mitral balloon valvuloplasty (PMV) were analyzed in 84 consecutive patients and PVLAP was defined as V wave 10 mm Hg higher than mean left atrial pressure (MLAP). RESULTS: PVLAP was observed in 45% (38/84) and factors associated with PVLAP were younger age (p=0.02), higher MLAP (p<0.01), higher mitral gradient (p=0.04), smaller valve area (p=0.01) and low echo score (p=0.02): among them MLAP was the only independent factor in multivariate analysis. The presence of PVLAP had no effect on the result of PMV and successful PMV abolished PVLAP. CONCLUSION: PVLAP was observed not infrequently in these selected patients with MS referred for PMV. The presence of PVLAP was not associated with MR and had good correlation with MLAP, which suggest that PVLAP be determined by decreased LAC.


Subject(s)
Humans , Atrial Pressure , Balloon Valvuloplasty , Catheterization , Catheters , Compliance , Hemodynamics , Mitral Valve Insufficiency , Mitral Valve Stenosis , Multivariate Analysis , Prevalence
12.
Korean Journal of Hepato-Biliary-Pancreatic Surgery ; : 177-187, 2000.
Article in Korean | WPRIM | ID: wpr-27339

ABSTRACT

BACKGROUND: Cystic neoplasms of pancreas comprise pathologically heterogeneous groups of tumors with many shared clinical features. Although relatively uncommon, they have a very important place in the surgical pathology of the pancreas because of their high cure rate and their potential confusion with far more common pancreatic pseudocysts. METHODS: We analysed clinical features of 23 patients with pancreatic cystic neoplasm that we treated within 8-years` period (13 women, 10 men, mean age; 47.2 years old) The cystic neoplasms of pancreas comprise 5 serous cystadenoma, 3 benign mucinous cystic tumor, 3 borderline malignancy of mucinous cystic tumor and 4 mucinous cystadenocarcinoma, 4 papillary cystic tumor, 1 cystic teratoma, 1 cystic mesothelioma, 1 lymphoepithelial cyst. 1 mucinous ductal ectasia. RESULTS: Mean tumor size was 6.8cm(3 to 15cm). 73.9 percent had abdominal pain and 26.1 percent had abdominal mass. Computed tomography, ultrasonography and MRI were useful in detecting cystic mass in all cases but was not reliable to distinguish serous from mucinous tumor, benign from malignant. For the treatment of the tumor, 17 distal pancreatectomy with splenectomy, 1 distal pancreatectomy with spleen preserving, 1 proximal pancreatic resection, 2 local excision of pancreas and 1 PPPD were performed. During the period of follow up (mean: 29 months) after surgical resection, 1 recurrence occurred in the patient who underwent local excision for mucinous cystic tumor showing borderline malignancy on histologic finding. All the patients are alive except 2 patients who were lost to follow-up. CONCLUSION: Pancreatic cystic neoplasms are rare and their prognosis are acceptable when they are treated early and properly. So early detection and surgical treatment is the mainstay of management of cystic neoplasm of pancreas.


Subject(s)
Female , Humans , Male , Abdominal Pain , Cystadenocarcinoma, Mucinous , Cystadenoma, Serous , Dilatation, Pathologic , Follow-Up Studies , Lost to Follow-Up , Magnetic Resonance Imaging , Mesothelioma, Cystic , Mucins , Pancreas , Pancreatectomy , Pancreatic Cyst , Pancreatic Pseudocyst , Pathology, Surgical , Prognosis , Recurrence , Spleen , Splenectomy , Teratoma , Ultrasonography
13.
Korean Journal of Infectious Diseases ; : 33-40, 2000.
Article in Korean | WPRIM | ID: wpr-36556

ABSTRACT

BACKGROUND: Modified Diamond medium (MDM) supplemented with 10% heat-inactivated horse serum, streptomycin, penicillin G, and mycostatin is commonly used for the isolation of Trichomonas vaginalis from vaginal swab. But, judging from our experience, the above usual MDM antibiotic composition was frequently contaminated with facultative anaerobes, and isolation rate of T. vaginalis was no more than 12% in 142 korean woman patients whose chief complaints were foul odored, increased vaginal discharge. This isolation rate is low in comparison with reports of another countries including U.S.A (about 15~30%) and could be attributed to the prevalence of antibiotic resistance in Korea. So, we exploited more selective antibiotic compositions in modified Diamond medium for pure isolation of T. vaginalis. METHODS: We used new self-devised anaerobic pack for sample maintenance and tested several antibacterial and antifungal agent combinations in modified Diamond medium supplemented with 5% human erythrocyte lysate and 5% heat-inactivated human serum in the place of 10% horse serum with the object of increased and pure isolation of T. vaginalis. Several drugs and chemicals were tested to fourteen wild strains isolated in a local clinic, in the hope of finding the agents that have no effect on T. vaginalis growth in high drug concentrations. Anaerobic jar was used for culture of T. vaginalis and cell count performed in the improved Neubauer's haemocytometer. RESULTS: Strains of T. vaginalis grew batter in modified Diamond medium supplemented with 5% human erythrocyte lysate and 5% heat-inactivated human serum (mean 1.166X106, about 5.83 fold) than 10% horse serum (mean 2.0X105 after 48 hours culture), and their growth rate in the former was more rapid than the latter in early grow phase. On the basis of this results, we examined selectivity of modified Diamond media supplemented with several antibacterial and antifungal combinations by a double blind test. Isolation rate in the conventional modified Diamond's medium (combination A; 10% horse serum, streptomycin 1,200 microgram/mL, penicillin G 1,500 unit/mL, mycostatin 37.5 microgram/mL, pH 6.2) was 9/73 (12.3%) while in modified Diamond medium supplemented with 5% human erythrocyte lysate and 5% heat-inactivated human serum, isolation rates in various drug combinations were as follows; Combination B (cefazolin 100 microgram/mL, streptomycin 1,200 microgram/mL, clindamycin 150 microgram/mL, pH 6.5), combination C (bacitracin 14.6 unit/mL, streptomycin 1,200 microgram/mL, clindamycin 150 microgram/mL pH 6.5) and combination D (vancomycin 100 microgram/mL, streptomycin 1,200 microgram/mL, clindamycin 150 microgram/mL pH 6.5) were all 11/73 (15.0%). Combination D allowed the least bacterial growth rate. CONCLUSION: We consider that a new modified Diamond medium supplemented with 5% human erythrocyte lysate, 5% heat-inactivated human serum and combination D might be provide the highest selection for Trichomonas vaginalis pure isolation from vaginal swabs.


Subject(s)
Female , Humans , Cell Count , Clindamycin , Diamond , Drug Combinations , Drug Resistance, Microbial , Erythrocytes , Hope , Horses , Hydrogen-Ion Concentration , Korea , Nystatin , Odorants , Penicillin G , Prevalence , Streptomycin , Trichomonas vaginalis , Trichomonas , Vaginal Discharge
15.
Korean Circulation Journal ; : 215-221, 1998.
Article in Korean | WPRIM | ID: wpr-200552

ABSTRACT

BACKGROUND: It is clinically important to evaluate myocardial viability after acute myocardial infarction. There are several methods like dobutamine stress echocardiography (DSE) and thallium scan to identify viable myocardium. Thallium SPECT assesses cellular integrity and dobutamine stress echocardiography assesses contractile reserve of myocardium. METHODS: Between March and August 1995, 30 consecutive patients (27 men and 3 women; mean age 52+/-12years) within 3 weeks after acute myocardial infarction were admitted to Asan Medical Center. Each underwent two-dimensional echocardiography before and during dobutamine infusion 8.6+/-6.5 days after acute myocardial infarction and thallium scan with rest-redistribution or stress-redistribution-reinjection protocol 8.1+/-6.4 days after acute myocardial infarction. Viability myocardium was considered if there were improvement in regional wall motion during dobutamine infusion (5, 10mg/kg/min for 5min and 20, 30mg/kg/min for 3min), With thallium SPECT, myocardial viability was considered if regional wall motion was normal, if perfusion defect, were either completely or partial mildly reversible, or if myocardial perfusion decreasedly or moderately and if irreversible perfusion was defect. Follow-up echocardiography was performed 3+/-1 months after acute myocardial infarction. Recovery of regional function was identified when follow-up echocardiography showed improvement of wall motion. We evaluated the accuracy of dobutamine stress echocardiography and thallium scan by concordant interpretation in acute and follow-up studies. RESULTS: Among the enrolled 30 patients, 27 patients had Q-wave MI. Thrombolysis was performed in 17 patients (57%) and PTCA was done in 18 patients (60%). The location of myocardial infarction wall in 20 patients and the inferior and lateral wall in 10 patients. Dobutamine stress echocardiography was performed safely in 30 patients 8.6+/-6.5 days after acute myocardial infarction. Improved wall motion was apparent in 15 patients (50%) after follow-up echocardiography 3+/-1 months after acute myocardial infarction. The positive and negative predictive values of dobutamine stress echocardiography were 14/17 (82%) and 12/13 (92%), respectively. Thallium SPECT was done in 26 patients 8.1+/-6.4 days after acute myocardial infarction. Among these 26 patients, follow-up echocardiography showed improved wall motion in 12 patients. The positive and negative predictive values of thallium SPECT were 9/10 (90%) and 13/16 (80%), respectively. Positive dobutamine stress echocardiography (r=0.46, p=0.001), positive thallium SPECT (r=0.44, p=0.003), hypokinetic segments (p=0.01) and non-anterior MI (p=0.02) were associated with reversible postischemic dysfunction. CONCLUSION: Dobutamine stress echocardiography (DSE) can be safely performed early after acute myocardial infarction. Both dobutamine stress echocardiography and thallium SPECT are reliable and complementary methods to diagnose viable myocardium.


Subject(s)
Female , Humans , Male , Dobutamine , Echocardiography , Echocardiography, Stress , Follow-Up Studies , Myocardial Infarction , Myocardium , Perfusion , Thallium , Tomography, Emission-Computed, Single-Photon
16.
Korean Journal of Anesthesiology ; : 5-17, 1998.
Article in Korean | WPRIM | ID: wpr-111778

ABSTRACT

INTRODUCTION: During an acute myocardial ischemia, maintenance of overall ventricular function may depend on remote nonischemic myocardium. Whereas fentanyl has minimal hemodynamic effects, volatile anesthetics, including halothane and isoflurane cause negative inotropic and lusitropic effects in normal myocardium. This investigation examined the effects of volatile anesthetics in comparision with fentanyl on compensatory responses to brief left anterior descending coronary artery (LAD) occlusion in remote normal myocardium (left circumflex coronary artery (LCX) supply) in an open-chest canine model. METHODS: Thirty-six mongrel dogs, acutely instrumented for measurement of pressure (left ventricle (LV) and aorta), flows (pulmonary trunk and LCX) and dimensions in ischemic and non-ischemic myocardium, were subjected to a 10-min LAD occlusion during fentanyl (n=10), halothane (n=13), or isoflurane (n=13) anesthesia. Regional contractile function was assessed using percent systolic shortening (%SS) and the preload recruitable stroke work slope (Mw). Diastolic function was evaluated using a regional time constant for intramyocardial pressure decline of LV (IMPtau), peak lengthening rate (dL/dtmax) and a regional chamber stiffness constant (Kp). RESULTS: Acute LAD occlusion caused immediate deterioration of anterior wall function similarly without changes in cardiac index, mean arterial pressure and dP/dtmax in all three groups. LV end-diastolic pressure (LVEDP), LVPtau, and heart rate increased and dP/dtmin decreased to the same extent with regional myocardial ischemia in all groups. During fentanyl anesthesia, acute myocardial ischemia was associated with an increase in %SS (26%) and Mw (48%) in LCX area without changes in IMPtau and dL/dtmax. With halothane or isoflurane anesthesia, %SS, Mw and IMPtau showed similar changes as those in fentanyl in response to LAD occlusion. However, dL/dtmax was increased (47 and 45% in the halothane and isoflurane groups, respectively) and Kp was increased (34 and 33% in the halothane and isoflurane groups, respectively) less compared to fentanyl (78%). Enhanced function in LCX zone was associated with a comparable increase (21~28% from baseline) in LCX flow in all groups. CONCLUSION: Enhanced regional contractility following acute coronary occlusion in nonischemic myocardium during fentanyl anesthesia is well-preserved with volatile anesthetics in an open-chest canine model. In addition, diastolic functions are also enhanced rather than depressed during anesthesia with volatile anesthetics. Halothane and isoflurane, however, do not differ in the compensatory responses to acute regional ischemia.


Subject(s)
Animals , Dogs , Anesthesia , Anesthetics , Arterial Pressure , Coronary Occlusion , Coronary Vessels , Fentanyl , Halothane , Heart Rate , Hemodynamics , Ischemia , Isoflurane , Myocardial Ischemia , Myocardium , Stroke , Ventricular Function
17.
Korean Journal of Medicine ; : 708-711, 1997.
Article in Korean | WPRIM | ID: wpr-111783

ABSTRACT

Dilated cardiomyopaty is a rare occurrence in Hecker muscular dystropy. We report a case of Becken muscular dystrophy in 28 old man who presented with dyspnea, progressive muscle weakness, and dilated cardiomyopathy with severe left ventricular dysfunction which was detected by echocardiograpy. Muscle biopsy demonstrated diffuse degenerated changes consistent with progressive muscular dystropy, His brother has also Becker muscular dystrophy and dilated cardiomyopathy, The patient is on NYHA Class II~III with medical therapy.


Subject(s)
Humans , Biopsy , Cardiomyopathy, Dilated , Dyspnea , Muscle Weakness , Muscular Dystrophies , Muscular Dystrophy, Duchenne , Siblings , Ventricular Dysfunction, Left
18.
The Journal of the Korean Orthopaedic Association ; : 86-91, 1996.
Article in Korean | WPRIM | ID: wpr-769849

ABSTRACT

The significance of the posterior cruciate ligament (PCL) in the stability of the knee and the necessity for surgical repair of its tears are still controversial. The purpose of this study is to present the short term results of surgical repair and Kennedy LAD augmentation for 15 cases with PCL injury. In 14 patients (15 knees), the torn PCL was repaired with pullout suture technique and Kennedy LAD augmentation was done from june 1993 to june 1994. The follow-up period ranged from 12 months to 25 months (average, 18months). The main causes of injuries were traffic accidents in 12. Thirteen of the patients were men and one was a woman, ranging in age from 17 to 52 years(average, 35 years). 10 knees were acute injury and repaired at average 9 days after injury. There were 11 cases that had combined injuries(4 ACL injuries, 4 meniscus injuries, 3 MCL injuries etc). In eight knees, the tear was in mid substance area and in five it was near femoral attach site and in two it was near tibial attach site. Postoperative results were evaluated by roentgenographic evaluation of posterior sagging and Lysholm knee score. 11 knee were stable but 4 knees were unstable posteriorly during postoperative follow-up period. 3 chronic injuried knees were included in 4 posteriorly unstable knees. There are 7 combined knee injuries in 11 stable knees and no combined injuries in unstable knees and average Lysholm knee score was 89.7 in stable knees and 90 in unstable knees and there was no significant difference between two groups. On the based of this study, surgical repair with pollout suture technique and augmentation with Kennedy LAD in acute PCL injury is a one of the good method for preventing posterior sagging but more longer follow-up period and more cases must be needed to accept this method.


Subject(s)
Female , Humans , Male , Accidents, Traffic , Follow-Up Studies , Knee , Knee Injuries , Lysholm Knee Score , Methods , Posterior Cruciate Ligament , Suture Techniques , Tears
20.
Journal of the Korean Pediatric Society ; : 934-938, 1983.
Article in Korean | WPRIM | ID: wpr-149329

ABSTRACT

No abstract available.


Subject(s)
Humans , Hyperbilirubinemia, Hereditary , Siblings
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